When a receptor on the surface of a T cell – a sentry of the human immune system – senses a single particle from a harmful intruder, it immediately kicks the cell into action, launching a larger immune response. But exactly how the signal from a single receptor, among thousands on each T cell, can be amplified to affect a whole cell has puzzled immunologists for decades.
Now, Salk scientists have discovered the key to the amplification of an “invader” signal. The T cell receptor that detects the intruder turns into a mini-machine, activating and releasing copy after copy of a protein called ZAP70.
In the image here, single molecule tracks of Zap70 overlaid with T cell receptor microclusters shows signal transfer at early moments of T cell activation.
The finding, published in Nature Immunology, could help scientists design better immune-mediated treatments for cancer or autoimmune diseases.
Originally published by Cosmos as Intruder alert
Cosmos
Curated content from the editorial staff at Cosmos Magazine.
Read science facts, not fiction...
There’s never been a more important time to explain the facts, cherish evidence-based knowledge and to showcase the latest scientific, technological and engineering breakthroughs. Cosmos is published by The Royal Institution of Australia, a charity dedicated to connecting people with the world of science. Financial contributions, however big or small, help us provide access to trusted science information at a time when the world needs it most. Please support us by making a donation or purchasing a subscription today.
