A cancer and its food supply


Researchers find surprise involvement of fat receptor.


A blood vessel (left) provides essential nutrients to a melanoma tumour in this artificially colorised microscopy image.

A blood vessel (left) provides essential nutrients to a melanoma tumour in this artificially colorised microscopy image.

Wellcome Images CC-BY-NC-ND

The blood vessel, on the left of this image, is a critical nutrient channel for the melanoma tumour seen at the right.

This image arises from research underway by a team led by Beate Heissig at the University of Tokyo Institute of Medical Science.

The scientists have identified a link between the progress of melanomas – which account for 1% of skin cancer cases by the majority of skin cancer deaths – and two molecules, tissue plasminogen activator (tPA) and low-density lipoprotein receptor-related protein 1 (LRP1).

"It's surprising that LRP1 is also regulating cancer growth and spread,” says Heissig. “It's normally a receptor for fat molecules.”

The research is published in the FASEB Journal.

Explore #Cancer #melanoma
  1. http://dx.doi.org/10.1096/fj.201801339RRR
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