5 October 2010

Father of IVF wins Nobel Prize

Agence France-Presse
Kicking off the week of Nobels, British IVF scientist Robert Edwards was awarded the The Nobel Prize in Medicine. A profile of the man who spent his career making the dream of having a baby come true for millions of people worldwide.
Robert Edwards

Robert Edwards - the father of the 'test-tube baby' - was awarded the Nobel Prize for Medicine, amid controversy. Credit: AFP

British scientist Robert Edwards believes that the most valuable thing in life is children – and spent his career making the dream of having a baby come true for millions of people worldwide.

He was awarded the Nobel Prize for Medicine, for his work on developing in vitro fertilisation (IVF), the science behind what became known as ‘test tube babies’.

Edwards, now a frail 85, finally saw his work recognised by the Nobel committee five decades after he first began experimenting and started on a path that would take him into conflict with the Catholic Church and fellow scientists.

He soon grasped that fertilisation outside the body could be a new way of treating infertility. Building on earlier research which showed that egg cells from rabbits could be fertilised in test tubes when sperm was added, Edwards developed the same technique for humans.

In a laboratory in Cambridge, eastern England, in 1968, he first saw life created outside the womb in the form of a human blastocyst, an embryo that has developed for five to six days after fertilisation.

“I’ll never forget the day I looked down the microscope and saw something funny in the cultures,” Edwards has recalled. “I looked down the microscope and what I saw was a human blastocyst gazing up at me. “I thought: ‘We’ve done it.”

But Edwards and his fellow researcher, gynaecological surgeon Patrick Steptoe, were forced to defend their work in the face of severe opposition, especially from the Catholic Church.

At a conference on biomedical ethics in Washington in 1971, the Nobel laureate James Watson, who with Francis Crick had discovered DNA, said IVF research would necessitate infanticide.

Addressing the conference, Edwards strongly defended his work and received a standing ovation. He remains convinced that the Catholic Church is wrong to object to IVF, saying clergy who condemn the technique are “totally mistaken”.

“Catholics are told not to do it and yet Catholics go and do it. All the popes have done for themselves is teach their people to disobey them,” Edwards has said.

His work was motivated by his belief that: “The most important thing in life is having a child. Nothing is more special than a child.” Edwards himself has five daughters and 11 grandchildren.

The culmination of his painstaking research came in 1978, with the birth of the world’s first test tube baby, Louise Brown.

Two years ago, Edwards spoke of his pride in his achievement as he celebrated Brown’s 30th birthday.
“I think the whole thing is incredible,” he said then, speaking fondly of Louise’s mother Lesley and now dead father John.

“When I go round the world I say this family were ordinary people… they were not brilliant people like Nobel Prize winners or anything. They were just ordinary.”

The Bourn Hall Clinic, the fertility centre which Edwards founded with Steptoe in Cambridge, has overseen the birth of more than 10,000 test tube babies.

Worldwide, births following IVF treatment are now commonplace. Nearly four million children worldwide are estimated to have been born thanks to the technique.

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